LEVELS 40+ Astral Runes. This is a really similar technique to RuneScape gold crafting Cosmic Runes. If you finished Lunar Diplomacy pursuit you may start crafting Astral Runes in Altar south-west of this village on Lunar Isle. Start by taking Runecrafting components, Earth personnel, Legislation runes and essences. While running to Altar watch out for 111 Combat level Suqahs which may hit you pretty hard if you don't pray for melee. Once you are finished making runes use Moonclan teleport and return to the bank to store what you created. This method will give you approximately 800k gold and 30k exp an hour following level 82 when you can craft double Astral Runes.
LEVELS 44+ Nature Runes. Another lucrative method of earning runes is done through Abyss. In case you have finished on level 1 Enter The Abyss miniquest you can now make use of it and craft Nature Runes and should not you will need to do that to use this method. Proceed to the wilderness north of Edgeville where you'll locate Mage of Zamorak by talking to the Dark Mage you can teleport into Abyss. Inside you'll be starting skulled so in the event that you die you will lose everything.
Use among many tunnels to become from the outer ring to the ring. You will have to do something to unblock barriers like mining stones (which requires mining level), or cutting woods that block the way take with you a cheap pickaxe or an axe. After you are done with that go into the Nature Altar portal site and make runes in the altar. Use Amulets of Glory into teleport back to Edgeville bank and repeat the process.
Remember that most of this procedure is performed at Wilderness so you may be attacked by others. It is worth risking your Graceful Outfit since it is readily retrieved but does not take anything more valuable with you. Although crafting Nature runes requires just 44 Runecrafting it is most profitable from 91 when you're able to create double Character Runes.
LEVELS 54+ Legislation and Death Runes. Later on it is possible to choose Death or Law Altar craft those at the Abyss. These Runes may be crafted equally to Nature ones although usually they aren't too profitable. You'll need to complete Dragon Slayer two to get Myths Guild allowing you to make Wrath Runes. You might also get Mythical cape that is not required but buy rs3 gold will let you teleport yourself really close to the Altar.